Epirubicin-Induced Oxidative DNA Damage and Evidence for Its Repair in Lymphocytes of Cancer Patients Who Are Undergoing Chemotherapy

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.

Keith C. Cheng, D S Cahill, Hiroshi Kasai et al. · Journal of Biological Chemistry · 1992 · 1.8K citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Doxorubicin cardiotoxicity: analysis of prevailing hypotheses

Richard D. Olson, Phillip S. Mushlin · The FASEB Journal · 1990 · 687 citations

Medicine, Pharmacology, Toxicology +16

Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome

Michael L. Wood, Miral Dizdaroglu, Ewa Gajewski et al. · Biochemistry · 1990 · 685 citations

Life Sciences, Genetics, Molecular Biology +16

Reactive oxygen species in tumorigenesis.

Daniel I. Feig, Thomas M. Reid, Lawrence A. Loeb · PubMed · 1994 · 476 citations

Life Sciences, Genetics, Molecular Biology +17

Site-specific mutagenesis using a gapped duplex vector: A study of translesion synthesis past 8-oxodeoxyguanosine in E. coli

Masaaki Moriya, C.-Y. Ou, Varun Bodepudi et al. · Mutation Research/DNA Repair · 1991 · 309 citations

Life Sciences, Biotechnology, Molecular Biology +16