Antagonism by olanzapine of dopamine D1, serotonin2, muscarinic, histamine H1 and α1-adrenergic receptors in vitro

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

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Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.

André DeLÉAN, Peter J. Munson, David Rodbard · American Journal of Physiology-Endocrinology and Metabolism · 1978 · 2.4K citations

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Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values.

Herbert Y. Meltzer, Shin Matsubara, J C Lee · Journal of Pharmacology and Experimental Therapeutics · 1989 · 1.4K citations

Medicine, Pharmacology, Psychiatry +17

Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding

Alain Schotte, Paul Janssen, W Gommeren et al. · Psychopharmacology · 1996 · 1.2K citations · Full text

Medicine, Pharmacology, Pharmacotherapy +11

Radioreceptor Binding Profile of the Atypical Antipsychotic Olanzapine

Frank P. Bymaster, David O. Calligaro, Julie F. Falcone et al. · Neuropsychopharmacology · 1996 · 1.1K citations · Full text

Medicine, Pharmacology, Pharmacotherapy +10