Concepedia

A Versatile Room‐Temperature Route to Di‐ and Trisubstituted Allenes Using Flow‐Generated Diazo Compounds

Jian‐Siang Poh, Duc N. Tran, Claudio Battilocchio, Joel M. Hawkins, Steven V. Ley

Angewandte Chemie International Edition · 2015 · 102 citations · 33 references

DOIFull text

Open access

Concepts

Abstract

A copper-catalyzed coupling reaction between flow-generated unstabilized diazo compounds and terminal alkynes provides di- and trisubstituted allenes. This extremely mild and rapid transformation is highly tolerant of several functional groups.

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