Highly Stable Pyrimidine‐Motif Triplex Formation at Physiological pH Values by a Bridged Nucleic Acid Analogue

Abstract

Good things come in threes: A novel bridged nucleic acid in which the furanose conformation was locked in the N form by a six-membered bridged moiety containing an NO bond (see picture) has been developed. Triplex-forming oligonucleotides composed of this residue formed highly stable triplexes at physiological pH values. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z604857_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.