Targeting of Lung Cancer Mutational Hotspots by Polycyclic Aromatic Hydrocarbons

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

Marc S. Greenblatt, W P Bennett, Monica Hollstein et al. · PubMed · 1994 · 3.5K citations

Tumor Biology, Cancer Pathology, Molecular Pathogenesis +9

Preferential Formation of Benzo[ <i>a</i> ]pyrene Adducts at Lung Cancer Mutational Hotspots in <i>P53</i>

Mikhail F. Denissenko, Annie Pao, Moon‐shong Tang et al. · Science · 1996 · 1.6K citations

Tumor Biology, Adduct Formation, Selective Adduct Formation +15

Molecular basis of base substitution hotspots in Escherichia coli

Christine Coulondre, Jeffrey H Miller, Philip J. Farabaugh et al. · Nature · 1978 · 1.2K citations

Escherichia Coli, Molecular Biology, Structural Genomics +5

5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

William M. Rideout, Gerhard A. Coetzee, Aria F. Olumi et al. · Science · 1990 · 638 citations

Chromatin, Human Ldl Receptor, Somatic Variant +15

Polycyclic aromatic hydrocarbons; chemistry and carcinogenicity

General Pharmacology The Vascular System · 1992 · 542 citations

Heterocyclic, Organic Chemistry, Toxicology +5