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Oligomerization of Cry11Aa from <i>Bacillus thuringiensis</i> Has an Important Role in Toxicity against <i>Aedes aegypti</i>

Carlos Muñóz-Garay, Claudia Rodríguez-Almazán, Jose N. Aguilar, Leivi Portugal, Isabel Gómez, Gloria Saab‐Rincón, Mário Soberón, Alejandra Bravo

Applied and Environmental Microbiology · 2009 · 30 citations · 15 references

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Abstract

Cry11Aa and Cyt1Aa of Bacillus thuringiensis are active against mosquitoes and show synergism. Cyt1Aa functions as a membrane receptor inducing Cry11Aa oligomerization. Here we characterized Cry11Aa helix alpha-3 mutants impaired in oligomerization and toxicity against Aedes aegypti, indicating that oligomerization of Cry11Aa is important for toxin action. Cyt1Aa did not recover the insecticidal activity of Cry11Aa mutants.

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