STUDIES ON A NEW ANTIVIRAL ANTIBIOTIC, 9-METHYLSTREPTIMIDONE. I

Abstract

A new antiviral agent which inhibits the growth of poliovirus, vesicular stomatitis virus (VSV) and Newcastle disease virus (NDV) was isolated from the culture filtrate of a Streptomyces and shown to be 3-(5, 7-dimethyl-4-oxo-2-hydroxy-6, 8-decadienyl)-glutarimide. The actue LD50 of the antibiotic in mice by intraperitoneal injection was 280 mg/kg. Serum specimens taken 10 minutes after intraperitoneal injection of 2.5 mg/kg to mice inhibited the growth of poliovirus.