A Nuclear Transport Inhibitor That Modulates the Unfolded Protein Response and Provides In Vivo Protection Against Lethal Dengue virus Infection - Concepedia

Concepedia

Publication | Open Access

A Nuclear Transport Inhibitor That Modulates the Unfolded Protein Response and Provides In Vivo Protection Against Lethal Dengue virus Infection

DOI Full Paper Access

102

Citations

43

References

2014

Year

Johanna E. Fraser, Satoru Watanabe, Chunxiao Wang, Wing Ki Chan, Belinda Maher, Adam J. López‐Denman, Caroline A. Hick, Kylie M. Wagstaff, Jason M. Mackenzie, Patrick M. Sexton,

The Journal of Infectious Diseases

Abstract

4-HPR is a novel antiviral that modulates the unfolded protein response, effective against DENV1-4 at concentrations achievable in the plasma in a clinical setting, and provides protection in a lethal mouse model.

References

	Year	Citations

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