BLOOD STUDIES IN INFANTS AND IN CHILDREN

Abstract

Introduction Review of the Literature Clinical and Pathologic Aspects Age Incidence Symptoms Physical Findings Roentgen Findings Hematological Data Hematological Data Following Splenectomy Other Laboratory Data Pathology Bone and Bone Marrow Spleen Liver and Lymph Glands Course and Prognosis Differential Diagnosis Treatment Comment Summary Report of Cases <h3>INTRODUCTION</h3> Erythroblastic anemia is a disturbance of the hematopoietic system characterized by a constant racial and familial incidence, a typical facial appearance, a progressing anemia with large numbers of nucleated erythrocytes in the peripheral blood, enlargement of the spleen, distinctive changes in the bones and, finally, histologic lesions in the bone marrow and spleen. The symptom complex is presumably not an entirely new one, but has been classified previously as atypical familial hemolytic anemia, as pernicious anemia, as splenic anemia and as von Jaksch's anemia or "pseudoleukemia infantum." The last name has been associated with many disturbances in infancy and childhood characterized by anemia,