Simvastatin alleviates cardiac fibrosis induced by infarction via up‐regulation of <scp>TGF</scp>‐β receptor <scp>III</scp> expression

Abstract

TGFBR3 mediated the decreased cardiac fibrosis, collagen deposition and fibroblast activity, induced by simvastatin, following MI. These effects involved GIPC inhibition of the ERK1/2/JNK pathway.