Mass spectrometry of laser‐desorbed oligonucleotides

Abstract

Abstract Various matrices were used for laser‐desorption ionization of mixtures of small DNA segments. Parent negative ions of 34‐mer as well as other smaller single‐stranded oligomers were observed for selected organic acids and dye compounds. Both positive and negative parent ions were observed with very little fragmentation. Effects of various matrices and the potential applications to DNA sequencing are briefly discussed.