Clinical and Vaccine Immunology · 2010 · 100 citations · 35 references
Veterinary MedicineImmunologyInfectious DiseasesImmunizationVaccinologyVirologyVaccinationVaccine-preventable DiseasesVector-based VaccinesViral InfectionsViral VaccinesViral Vector VaccinesAdenoviral Vaccine VectorsAdenovirus VaccinesBiological Threat PreparednessBiological Threat PreventionEbola VaccinesMultivalent Vaccine FormulationsPathogenic EffectsPrimate Infectious Diseases
Ebola viruses are highly pathogenic viruses that cause outbreaks of hemorrhagic fever in humans and other primates. To meet the need for a vaccine against the several types of Ebola viruses that cause human diseases, we developed a multivalent vaccine candidate (EBO7) that expresses the glycoproteins of Zaire ebolavirus (ZEBOV) and Sudan ebolavirus (SEBOV) in a single complex adenovirus-based vector (CAdVax). We evaluated our vaccine in nonhuman primates against the parenteral and aerosol routes of lethal challenge. EBO7 vaccine provided protection against both Ebola viruses by either route of infection. Significantly, protection against SEBOV given as an aerosol challenge, which has not previously been shown, could be achieved with a boosting vaccination. These results demonstrate the feasibility of creating a robust, multivalent Ebola virus vaccine that would be effective in the event of a natural virus outbreak or biological threat.
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Fruit bats as reservoirs of Ebola virus
Eric M. Leroy, Brice Kumulungui, Xavier Pourrut et al. · Nature · 2005 · 1.6K citations · Full text
Virus Taxonomy: VIIIth Report of the International Committee on Taxonomy of Viruses.
C. M. Fauquet, M. A. Mayo, Jack Maniloff et al. · 2005 · 802 citations