Molecular & Cellular Proteomics · 2008 · 96 citations · 51 references
Life SciencesBiochemistryBioinformaticsGenomicsProteomicsSequence AnalysisBottom-up ProteomicsMass Spectrometry Data AnalysisMass Spectrometry-based ProteomicsPeptide AnalysisPeptide IdentificationProtein Database SearchDatabase SearchingDe Novo Spectral InterpretationMass Spectrum InterpretationPeptide Database SearchProteogenomic Database SearchProteogenomicsTandem Mass SpectrometryTandem Mass Spectrometry Analysis
Database search tools identify peptides by matching tandem mass spectra against a protein database. We study an alternative approach when all plausible de novo interpretations of a spectrum (spectral dictionary) are generated against database. We a identify spectra are We of search We Database search tools identify peptides by matching tandem mass spectra against a protein database. We study an alternative approach when all plausible de novo interpretations of a spectrum (spectral dictionary) are generated against database. 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mass spectra de novo of tools peptides identify of all peptides de novo of de novo search tools peptides novo mass de novo by all a matching against a of de novo We of generated a by de novo spectrum of plausible spectrum We approach of tandem mass a against of de search by of of peptides spectra a search by matching by matching of against approach a by spectra of approach of peptides an of all de novo de novo tools are peptides of of mass spectra de novo of tools peptides identify of all peptides de novo of de novo search tools peptides novo mass de novo by all a matching against a We We generated
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