Concepedia

Epidermal Growth Factor Receptor Controls Flat Dysplastic Aberrant Crypt Foci Development and Colon Cancer Progression in the Rat Azoxymethane Model

Urszula Dougherty, Amikar Sehdev, Reba Mustafi, Nathaniel Little, Weihua Yuan, Sujatha Jagadeeswaran, Anusara Chumsangsri, Jorge Delgado, Maria Tretiakova, Loren Joseph,

Clinical Cancer Research · 2008 · 51 citations · 51 references

DOIFull text

Open access

Abstract

We have shown for the first time that EGFR promotes the development of flat dysplastic ACF and the progression of malignant colonic tumors. Furthermore, we have mechanistically identified several transcription factors and their targets as EGFR effectors in colonic carcinogenesis.

References

51

Primer3 on the WWW for General Users and for Biologist Programmers

Steve Rozen, Helen Skaletsky · Humana Press eBooks · 2003 · 15K citations

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β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

Osamu Tetsu, Frank McCormick · Nature · 1999 · 3.6K citations

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Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

Charles E. Eberhart, R J Coffey, Radhika Aramandla et al. · Gastroenterology · 1994 · 2.5K citations · Full text

Expression of Epiregulin and Amphiregulin and <i>K-ras</i> Mutation Status Predict Disease Control in Metastatic Colorectal Cancer Patients Treated With Cetuximab

Shirin Khambata‐Ford, Christopher R. Garrett, Neal J. Meropol et al. · Journal of Clinical Oncology · 2007 · 1.1K citations · Full text

A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor.

Fortunato Ciardiello, Giampaolo Tortora · PubMed · 2001 · 988 citations

, , +18