Fabrication of Chemical Microarrays by Efficient Immobilization of Hydrazide‐Linked Substances on Epoxide‐Coated Glass Surfaces

Myung‐Ryul Lee, Injae Shin

Angewandte Chemie International Edition · 2005 · 93 citations · 15 references

Concepts

Abstract

Fixed to the spot: A new, efficient, and simple immobilization technique for the construction of chemical microarrays has been developed. This technique is applicable to the site-selective attachment of diverse substances, including small molecules, carbohydrates, and peptides, to glass slides (see picture). The chemical microarrays fabricated by using this method were applied to screening peptide and small-molecule binding to proteins.

References

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