Treatment of cicatricial pemphigoid with tetracycline and nicotinamide

Abstract

Cicatricial pemphigoid is a rare autoimmune blistering disease involving predominantly mucosal areas in elderly patients. It runs a chronic relapsing course. Immunosuppressive treatments are frequently complicated by adverse effects and require careful monitoring. A 69-year-old woman is reported who responded well to a simple regimen of combined tetracycline and nicotinamide after 15 years of inadequate disease control and numerous adverse effects from immunosuppressive agents.