Additional Genetic High-Risk Features Such As 11q Deletion, 17p Deletion, and <i>V3-21</i> Usage Characterize Discordance of ZAP-70 and <i>VH</i> Mutation Status in Chronic Lymphocytic Leukemia

Abstract

There were characteristic modes of discordance between ZAP-70 and VH mutation status depending on the presence or absence of additional genetic high-risk features such as 11q and 17p deletion or V3-21 usage. Although the biologic background for these findings is yet to be determined, these data have biologic and clinical implications regarding ZAP-70 as a pathogenic factor and outcome predictor, respectively.