Concepedia

[Hydroxy(tosyloxy)iodo]benzene Mediated α-Azidation of Ketones

Om Prakash, Kamaljeet Pannu, Richa Prakash, Anita Batra

Molecules · 2006 · 26 citations · 9 references

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Abstract

Reaction of various ketones with [hydroxy(tosyloxy)iodo]benzene (HTIB) followed by treatment of the alpha-tosyloxy ketones thus generated in situ with NaN3 offers a one-pot procedure for the synthesis of alpha-azido ketones. The HTIB used in this conversion may also be generated in situ by using iodosobenzene in combination with p-toluene-sulphonic acid.

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