Concepedia

The Novel Pyrrolidine Nor-Lobelane Analog UKCP-110 [cis-2,5-di-(2-phenethyl)-pyrrolidine hydrochloride] Inhibits VMAT2 Function, Methamphetamine-Evoked Dopamine Release, and Methamphetamine Self-Administration in Rats

Joshua S. Beckmann, Kiran B. Siripurapu, Justin R. Nickell, David B. Horton, Emily D. Denehy, Ashish P. Vartak, Peter A. Crooks, Linda P. Dwoskin, Michael T. Bardo

Journal of Pharmacology and Experimental Therapeutics · 2010 · 25 citations · 29 references

Open access

References

29

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport

David Sulzer, T J H Chen, YY Lau et al. · Journal of Neuroscience · 1995 · 687 citations · Full text

Life Sciences, Neurobiology, Neuroscience +14

VMAT2 knockout mice: Heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity

Nobuyuki Takahashi, Lucinda L. Miner, Ichiro Sora et al. · Proceedings of the National Academy of Sciences · 1997 · 429 citations

Life Sciences, Neuroscience, Pharmacology +17

Knockout of the Vesicular Monoamine Transporter 2 Gene Results in Neonatal Death and Supersensitivity to Cocaine and Amphetamine

Yan-Min Wang, Raul R. Gainetdinov, Fabio Fumagalli et al. · Neuron · 1997 · 380 citations · Full text

Life Sciences, Neurobiology, Neuroscience +15

STUDIES ON BEHAVIOR. IV. STIMULANT ACTIONS OF METHAMPHETAMINE

Peter Dews · Journal of Pharmacology and Experimental Therapeutics · 1958 · 360 citations

Medicine, Behavioral Sciences, Pharmacology +13