Effects of Roxithromycin on Tumor Necrosis Factor‐Alpha‐Induced Vascular Endothelial Growth Factor Expression in Human Periodontal Ligament Cells in Culture

Abstract

These results indicate that TNF-alpha, one of the proinflammatory cytokines implicated in the pathogenesis of periodontitis, induces excess induction of VEGF in HPDL, which may account for increased angiogenesis in periodontitis lesions. Interestingly, the antibiotic roxithromycin inhibits TNF-mediated VEGF induction, suggesting its possible therapeutic utility in periodontitis and other chronic inflammatory conditions involving VEGF induction.