Novel pyrrolopyrimidine analogues as potent dipeptidyl peptidase IV inhibitors based on pharmacokinetic property-driven optimization

(2<i>R</i>)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-<i>a</i>]pyrazin- 7(8<i>H</i>)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine:  A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

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Pharmacy, Medicinal Chemistry, Pharmacology +15

Polar Molecular Surface Properties Predict the Intestinal Absorption of Drugs in Humans

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Pharmacy, Pharmacokinetics, Pharmacology +14

Discovery and Preclinical Profile of Saxagliptin (BMS-477118):  A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

David J. Augeri, Jeffrey A. Robl, David A. Betebenner et al. · Journal of Medicinal Chemistry · 2005 · 621 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10

Non-conventional methodologies for transition-metal catalysed carbon–carbon coupling: a critical overview. Part 2: The Suzuki reaction

Francisco Alonso, I. P. Beletskaya, Miguel Yus · Tetrahedron · 2007 · 528 citations

Natural Sciences, Chemical Engineering, Chemistry +13

Non-conventional methodologies for transition-metal catalysed carbon–carbon coupling: a critical overview. Part 1: The Heck reaction

Francisco Alonso, I. P. Beletskaya, Miguel Yus · Tetrahedron · 2005 · 494 citations

Natural Sciences, Chemistry, Catalysis +12