Time to knit · 2000 · 13 citations · 31 references
PharmacyMedicinal ChemistryPharmacologyAgingDrug DiscoveryGlycobiologyEnzyme InhibitionNatural Product Drug DiscoveryAdvanced Glycation End ProductsGlycosylation In DiseaseIndirect EffectsMetabolic TherapiesProtein GlycoxidationRheumatoid Arthritis Pharmacotherapy
It is now well established that non enzymatic glycation leads to formation of Amadori products which over course of time leads to formation of advanced glycation end products (AGEs). Accumulation of AGEs is very toxic and can have direct and indirect effects in the pathogenesis of various diseases including diabetes, alzheimer’s disease, rheumatoid arthritis etc. Hence, to curb these harmful effects, a number of natural and synthetic compounds are being investigated so as to reduce clinica
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An agent cleaving glucose-derived protein crosslinks in vitro and in vivo
Sara Vasan, Xin Zhang, Xini Zhang et al. · Nature · 1996 · 471 citations