Interindividual Variability in Tpmt Enzyme Activity: 10 Years of Experience with Thiopurine Pharmacogenetics and Therapeutic Drug Monitoring

Abstract

These results illustrate the usefulness of pharmacogenomics and metabolite measurement to improve the identification of noncompliance and patients at high risk for toxicity or therapeutic resistance. Original submitted 13 November 2013; Revision submitted 30 January 2014.