Multiple sclerosis rebound following herpes zoster infection and suspension of fingolimod

Abstract

Fingolimod, a sphingosine 1-phosphate receptor modulator, is highly effective in the treatment of multiple sclerosis (MS).[1][1],[2][2] However, fatal cases of herpes infection have occurred in 2 patients on fingolimod therapy, 1 of whom presented with a primary disseminated varicella-zoster virus (