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An Improved Process for the N‐Demethylation of Opiate Alkaloids using an Iron(II) Catalyst in Acetate Buffer
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Citations
17
References
2009
Year
Pharmaceutical ScienceBioorganic ChemistryN‐demethylate Opiate AlkaloidsAcetate BufferSecondary MetaboliteOrganic ChemistryChemistryPharmaceutical ChemistryDiversity Oriented SynthesisFerrous PorphyrinBiochemistryCatalysisNatural Product SynthesisPharmacologyOpiate AlkaloidsEnantioselective SynthesisNatural SciencesImproved ProcessMedicineSynthetic ChemistryDrug DiscoveryDrug Analysis
Abstract An improved process to N‐demethylate opiate alkaloids utilising a solution of the ferrous porphyrin, tetrasodium 5,10,15,20‐tetra(4‐sulfophenyl)porphyrinatoiron(II) [=Fe(II)‐TPPS ( 8 )], in acetate buffer is described. This method provided the corresponding N‐demethylated opiates in good yield with high reproducibility.
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