DNA‐Controlled Reversible Switching of Peptide Conformation and Bioactivity

Abstract

A DNA switch: Hybridization with DNA controls the conformation of a peptide nucleic acid (PNA)–peptide conjugate. This reversible process can activate (see scheme) or deactivate the binding propensity of the peptide for a protein target involved in cellular signal transduction. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z603889_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.