Salicylate and Salicyl Conjugates: Fluorimetric Estimation, Biosynthesis and Renal Excretion in Man1

Abstract

Three urinary salicyl conjugates account for over 80 per cent of salicylate ingested by a normal subject excreting acid urine (1-4). The metabo- lites, which are estimated by specific methods, are salicylurate, salicyl acyl glucuronide, and salicyl phenolic glucuronide Alkaline urines also contain the same conjugates plus variable amounts of salicylate (5-8). With the existing methods, only salicylate has been detected in human plasma (9). It has been suggested, therefore, that the salicyl conjugates are formed within the kidney in man (