The Tarantula Toxins ProTx-II and Huwentoxin-IV Differentially Interact with Human Nav1.7 Voltage Sensors to Inhibit Channel Activation and Inactivation

An SCN9A channelopathy causes congenital inability to experience pain

James J. Cox, Frank Reimann, Adeline K. Nicholas et al. · Nature · 2006 · 1.6K citations · Full text

Life Sciences, Neurobiology, Neuroscience +11

Molecular Determinants of High Affinity Binding of α-Scorpion Toxin and Sea Anemone Toxin in the S3-S4 Extracellular Loop in Domain IV of the Na+ Channel α Subunit

John C. Rogers, Yusheng Qu, Timothy N. Tanada et al. · Journal of Biological Chemistry · 1996 · 412 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Molecular Basis of an Inherited Epilepsy

Christoph Lossin, Dao Wen Wang, Thomas H. Rhodes et al. · Neuron · 2002 · 365 citations · Full text

Medicine, Genetics, Molecular Genetics +14

Structure and functional expression of a new member of the tetrodotoxin‐sensitive voltage‐activated sodium channel family from human neuroendocrine cells.

Norbert Klugbauer, Ľubica Lacinová, Veit Flockerzi et al. · The EMBO Journal · 1995 · 323 citations · Full text

Natural Sciences, Pharmacology, Physiology +17

Nav1.3 Sodium Channels: Rapid Repriming and Slow Closed-State Inactivation Display Quantitative Differences after Expression in a Mammalian Cell Line and in Spinal Sensory Neurons

Theodore Cummins, Fabio Aglieco, Raimund I. Herzog et al. · Journal of Neuroscience · 2001 · 316 citations · Full text

Life Sciences, Neuroscience, Physiology +17