Concepedia

Effect of extracellular vesicles of human adipose tissue on insulin signaling in liver and muscle cells

Mariëtte E.G. Kranendonk, Frank L.J. Visseren, Joost A. van Herwaarden, Esther N. M. Nolte‐‘t Hoen, Wilco de Jager, Marca H. M. Wauben, Eric Kalkhoven

Obesity · 2014 · 183 citations · 32 references

DOIFull text

Open access

Abstract

Human AT-EVs can stimulate or inhibit insulin signaling in hepatocytes- possibly depending on their adipokine content- and may thereby contribute to systemic IR.

References

32

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Gökhan S. Hotamışlıgil, Narinder S. Shargill, Bruce M. Spiegelman · Science · 1993 · 7.4K citations

Prevalence of the Metabolic Syndrome Among US Adults

Earl S. Ford, Wayne H. Giles, William H. Dietz · JAMA · 2002 · 6.7K citations

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Haiyan Xu, Glenn T. Barnes, Qing Yang et al. · Journal of Clinical Investigation · 2003 · 5.8K citations · Full text

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Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids

Clotilde Théry, Sebastián Amigorena, Graça Raposo et al. · Current Protocols in Cell Biology · 2006 · 5.7K citations

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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Haiyan Xu, Glenn T. Barnes, Qing Yang et al. · Journal of Clinical Investigation · 2003 · 5.6K citations

, , +18