Nanomedicine · 2015 · 41 citations · 16 references
PharmacyPharmacokineticsPharmacologyBiomedical ImagingDiagnostic ImagingDrug DeliveryElectron Paramagnetic ResonanceMagnetic Resonance ImagingMagnetic Resonance SpectroscopyNanomaterials For Drug DeliveryNanomedicineNanoparticle CharacterizationElectron Paramagnetic Resonance ImagingIron Oxide NanoparticlesMagnetic Nanoparticle BiodistributionMagnetic Nanoparticle Drug CarriersMagnetic Oxide NanoparticlesNanoparticle-based Contrast AgentsPharmacokinetic ParametersSuperparamagnetic Contrast Agents
AIM: Superparamagnetic iron oxide nanoparticles (SPIONs) may play an important role in nanomedicine by serving as drug carriers and imaging agents. In this study, we present the biodistribution and pharmacokinetic properties of SPIONs using a new detection method, particle electron paramagnetic resonance (pEPR). MATERIALS & METHODS: The pEPR technique is based on a low-field and low-frequency electron paramagnetic resonance. pEPR was compared with inductively coupled plasma mass spectrometry and MRI, in in vitro and in vivo. RESULTS: The pEPR, inductively coupled plasma mass spectrometry and MRI results showed a good correlation between the techniques. CONCLUSION: The results indicate that pEPR can be used to detect SPIONs in both preclinical and clinical studies.
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