BLADDER RECONSTITUTION WITH BONE MARROW DERIVED STEM CELLS SEEDED ON SMALL INTESTINAL SUBMUCOSA IMPROVES MORPHOLOGICAL AND MOLECULAR COMPOSITION

Abstract

Bladder reconstitution occurs more rapidly using stem cell seeded SIS. Although in USG and SSG all 3 cellular constituents appear to develop by 3 months, only SSG had gene expression levels similar to those in controls. The results suggest an explanation for the fibrosis noted in unseeded SIS bladder augmentations and the possible solution using stem cells.