Concepedia

A protocol for amide bond formation with electron deficient amines and sterically hindered substrates

Maria E. Due‐Hansen, Sunil K. Pandey, Elisabeth Christiansen, Rikke Sick Andersen, Steffen V. F. Hansen, Trond Ulven

Organic & Biomolecular Chemistry · 2015 · 97 citations · 24 references

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Concepts

Abstract

A protocol for amide coupling by in situ formation of acyl fluorides and reaction with amines at elevated temperature has been developed and found to be efficient for coupling of sterically hindered substrates and electron deficient amines where standard methods failed.

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