Clinical Chemistry · 1969 · 39 citations · 8 references
PharmacyPharmaceuticsPharmacologyAnalytical ChemistryBioavailabilityTherapeutic Drug MonitoringDrug DispositionFluorescence SpectroscopyMethod DevelopmentPlasma Medicine
Abstract A method is described for the determination of plasma methotrexate at low concentrations. The method consists of a single fluorescence measurement on plasma proteinfree filtrates after oxidation of the drug with KMnO4 at controlled pH. The complete release of the drug into plasma filtrates is accomplished by heating the reaction mixture in a boiling water bath with occasional stirring.
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Cirrhosis Associated With Methotrexate Treatment of Psoriasis
R. Owen Coe · JAMA · 1968 · 114 citations