Concepedia

Leukocyte‐Specific Protein 1: A Novel Regulator of Hepatocellular Proliferation and Migration Deleted in Human Hepatocellular Carcinoma

Kelly Koral, Shirish Paranjpe, William C. Bowen, Wendy M. Mars, Jianhua Luo, George K. Michalopoulos

Hepatology · 2014 · 30 citations · 13 references

DOIFull text

Open access

Abstract

LSP1 is expressed in normal hepatocytes and liver after PHx after termination of proliferation. In rat hepatoma cell lines and mouse liver in vivo, LSP1 functions as a negative regulator of proliferation and migration. Given the high frequency of LSP1 CNV in human HCC, LSP1 may be a novel target for diagnosis and treatment of HCC.

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