Targeted gene delivery in tumor xenografts by the combination of ultrasound-targeted microbubble destruction and polyethylenimine to inhibit survivin gene expression and induce apoptosis

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.

Otmane Boussif, Frank Lezoualc’h, Maria Antonietta Zanta et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations · Full text

Engineering, In Vivo Gene Therapy, Several Polycations +20

Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis

Jerry E. Chipuk, Tomomi Kuwana, Lisa Bouchier‐Hayes et al. · Science · 2004 · 2K citations

Apoptosis, Molecular Biology, Cell Death +19

Control of apoptosis and mitotic spindle checkpoint by survivin

Fengzhi Li, Grazia Ambrosini, Emily Chu et al. · Nature · 1998 · 1.9K citations

Cell Division, Apoptosis, Mitotic Spindle Checkpoint +6

Caspases 3 and 7: Key Mediators of Mitochondrial Events of Apoptosis

Saquib A. Lakhani, Ali J. Masud, Keisuke Kuida et al. · Science · 2006 · 1.2K citations · Full text

Current Model, Apoptosis, Immunology +16

Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application

Ralf Kircheis, Lionel Wightman, Alan D. Schreiber et al. · Gene Therapy · 2001 · 351 citations

Polyethylenimine/dna Complexes, Tumor Biology, Systemic Application +9