Lower Cognitive Performance in Normal Older Adult Male Twins Carrying the Apolipoprotein E 4 Allele

Abstract

The apoE epsilon 4 allele may be associated with decreased cognitive function in discordant twin pairs. Our results suggest that epsilon 4 may represent a potential marker for accelerated cognitive aging and such individuals may be at greater risk for development of late-onset Alzheimer dementia or multi-infarct dementia.