Epidemics · 2014 · 48 citations · 18 references
Veterinary MedicineImmunologyInfectious DiseasesClinical ImmunologyHost-pathogen InteractionsImmunology Of Infectious DiseasesDisease ModelingImmune Responses To InfectionImmune System ModelingImmunological Disease ModelsInfectious Disease DynamicsMarkov Chain Monte CarloAntibody DistributionHierarchical Bayesian EstimationImmunological ModelingMarkov Chain Monte Carlo EstimationSerological ProfilingSubclinical InfectionsWithin-host Disease ModelingWithin-host Dynamics
We present a simple phenomenological within-host model describing both the interaction between a pathogen and the immune system and the waning of immunity after clearing of the pathogen. We implement the model into a Bayesian hierarchical framework to estimate its parameters for pertussis using Markov chain Monte Carlo methods. We show that the model captures some essential features of the kinetics of titers of IgG against pertussis toxin. We identify a threshold antibody level that separates a large increase in antibody level upon infection from a small increase and accordingly might be interpreted as a threshold separating clinical from subclinical infections. We contrast predictions of the model with observations reported in the literature and based on independent data and find a remarkable correspondence.
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