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Molecular screening of patients with long standing extensive ulcerative colitis: detection of p53 and Ki- <i>ras</i> mutations by single strand conformation polymorphism analysis and differential hybridisation in colonic lavage fluid

Susanna Lang, D. Stratakis, M. Heinzlmann, Walter Heldwein, B. Wiebecke, K. Loeschke

Gut · 1999 · 29 citations · 25 references

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Abstract

Mutations were more frequent in patients with long standing ulcerative colitis (19%) than in control patients (3%, p = 0.07). The technique may be useful for screening for early malignancy in ulcerative colitis.

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C D Gillen, Russell S. Walmsley, P Prior et al. · Gut · 1994 · 513 citations · Full text