Endocrinology · 1986 · 44 citations · 10 references
MedicineEndocrinologyPhysiologyHormone BiochemistryNeuroendocrinologyReproductive EndocrinologyGonadal EndocrinologyGonadal HormonesHypothalamic-pituitary AxisHypothalamic-pituitary RegulationHypothalamic-pituitary-gonadal AxisPituitary HormonesHypothalamic Regulation Of ReproductionHypothalamic-pituitary-gonadal Axis RegulationPituitary Gland AnatomyPituitary Gonadotroph FunctionPituitary Peptide HormonesPituitary PhysiologyPituitary-gonadal AxisPost-translational Protein Processing
Pro-dynorphin peptides have been shown to exist in the anterior lobe of the pituitary gland. The dynorphin in the anterior lobe is distinct from that which is co-localized with vasopressin in the magnocellular system in both post-translational processing and regulation of release. Here, we report on the existence of pro-dynorphin mRNA, approximately 2400 nucleotides in length, in the anterior lobe. Furthermore, we present immunocytochemical evidence for the co-existence of dynorphin, LH and FSH in a subset of gonadotrophs. These findings suggest a possible role of pro-dynorphin products in the regulation of the hypothalamic-pituitary-gonadal axis.
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Cloning and sequence analysis of cDNA for porcine β-neo-endorphin/dynorphin precursor
Hitoshi Kakidani, Yasuji Furutani, Hideo Takahashi et al. · Nature · 1982 · 781 citations
Anatomy of the CNS opioid systems
Henry Khachaturian, Michael E. Lewis, Martin Schäfer et al. · Trends in Neurosciences · 1985 · 434 citations · Full text
Sequence and expression of the rat prodynorphin gene.
Olivier Civelli, J Douglass, A Goldstein et al. · Proceedings of the National Academy of Sciences · 1985 · 386 citations · Full text