Stereodivergent Synthesis of Substituted N,O‐Containing Bicyclic Compounds by Sequential Addition of Nucleophiles to <i>N</i>‐Alkoxybicyclolactams

Abstract

In control! N-alkoxybicyclolactams derived from the ring-rearrangement metathesis of nitroso Diels–Alder cycloadducts were subjected to the successive addition of two nucleophiles to yield substituted piperidine or pyrrolidine precursors with good to excellent stereoselectivity. The relative configuration of the newly formed stereocenter can be controlled by the order of addition of the two nucleophiles. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.