Proceedings of the National Academy of Sciences · 1994 · 300 citations · 33 references
Life SciencesMedicinal ChemistryMolecular BiologyDrug DiscoveryMolecular VirologyVirologyAntiretroviral TherapyAntiviral PharmacologyOligonucleotide ChemistryRna StructureViral StructureViral TropismAntiviral Drug DesignAntiviral Structure-activity RelationshipsCombinatorial Library ScreeningCombinatorial ScreeningHiv Antiretroviral TherapyNucleoside AnalogsOligonucleotide HybridizationPhosphorothioate Chemistry
The phosphorothioate oligonucleotide T2G4T2 was identified as an inhibitor of HIV infection in vitro by combinatorial screening of a library of phosphorothioate oligonucleotides that contained all possible octanucleotide sequences. The oligonucleotide forms a parallel-stranded tetrameric guanosine-quartet structure. Tetramer formation and the phosphorothioate backbone are essential for antiviral activity. The tetramer binds to the human immunodeficiency virus envelope protein gp120 at the V3 loop and inhibits both cell-to-cell and virus-to-cell infection.
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Selection of single-stranded DNA molecules that bind and inhibit human thrombin
Louis C. Bock, Linda C. Griffin, John Latham et al. · Nature · 1992 · 2.5K citations
Continuous culture of human lymphoblasts from peripheral blood of a child with acute leukemia
George E. Foley, Herbert Lazarus, Sidney Farber et al. · Cancer · 1965 · 1.2K citations · Full text
Medicine, Cell Biology, Hematology +14