Proceedings of the National Academy of Sciences · 1987 · 146 citations · 24 references
MedicineOncologyPharmacologyCancer PharmacologyChemotherapyMolecular OncologyAntibody ConjugatesAntibody ConjugationAntibody-drug ConjugatesCellular Drug EffluxChemotherapy ResistanceMultidrug ResistanceAntibody - Toxin ConjugatesAntibody-drug Conjugate AntibodiesAntibody-drug Conjugate TherapyAntibody-toxin ConjugatesDrug-protein ConjugatesMultidrug Resistance TransportOvercoming Multidrug ResistanceReversal Of Drug Resistance
One form of multidrug resistance is due to the expression of a 170-kDa energy-dependent drug efflux pump called P-glycoprotein in the plasma membranes of human cancer cells. We have prepared conjugates of Pseudomonas toxin with the anti-P-glycoprotein monoclonal antibody MRK-16. These anti-P-glycoprotein-toxin conjugates specifically kill multidrug-resistant human KB cells. Similar conjugates could be useful in cancer therapy to reduce or eliminate multidrug-resistant tumor populations in tumors intrinsically resistant to chemotherapy or in populations that become resistant during combination chemotherapy.
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Kazumitsu Ueda, Carol Cardarelli, Michael M. Gottesman et al. · Proceedings of the National Academy of Sciences · 1987 · 1.1K citations · Full text