A large-scale synthesis of somatostatin for clinical use by a novel alternating solution/solid-phase procedure

Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone

Paul Brazeau, Wylie Vale, Roger Burgus et al. · Science · 1973 · 3.5K citations

Medicine, Biochemistry, Endocrinology +16

A New Method of Forming Peptide Bonds

John C. Sheehan, George P. Hess · Journal of the American Chemical Society · 1955 · 1.3K citations

Life Sciences, Biochemistry, Chemistry +5

A Method of Synthesis of Long Peptide Chains Using a Synthesis of Oxytocin as an Example

Miklos Bodanszky, Vincent du Vigneaud · Journal of the American Chemical Society · 1959 · 511 citations

Life Sciences, Biochemistry, Bioisosterism +5

Acetamidomethyl. A Novel Thiol Protecting Group for Cysteine

Daniel F. Veber, John D. Milkowski, Sándor Varga et al. · Journal of the American Chemical Society · 1972 · 314 citations

Natural Sciences, Biochemistry, Chemistry +8

SOLID‐PHASE PEPTIDE SYNTHESIS USING MILD BASE CLEAVAGE OF <i>N</i>_αFLUORENYLMETHYLOXYCARBONYLAMINO ACIDS, EXEMPLIFIED BY A SYNTHESIS OF DIHYDROSOMATOSTATIN

Chi‐Deu Chang, Johannes Meienhofer · International journal of peptide & protein research · 1978 · 302 citations

Pharmacy, Biochemistry, Medicinal Chemistry +15