Highly Regio‐ and Stereoselective Three‐Component Nickel‐Catalyzed <i>syn</i>‐Hydrocarboxylation of Alkynes with Diethyl Zinc and Carbon Dioxide

Abstract

Hydrocarboxylation of alkynes: The first example of nickel-catalyzed hydrozincation of alkynes that form stereodefined hydrocarboxylation products is presented (see scheme; cod=cycloocta-1,5-diene). This catalytic system is efficient for the activation of CO2 and the three-component reaction produces products that could be converted into important oxindole or γ-butyrolactam derivatives.