FAS expression inversely correlates with PTEN level in prostate cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis

Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

Shunyou Wang, Jing Gao, Qun‐Ying Lei et al. · Cancer Cell · 2003 · 1.1K citations · Full text

Medicine, Molecular Genetics, Oncology +15

Orlistat Is a Novel Inhibitor of Fatty Acid Synthase with Antitumor Activity

Steven J. Kridel, Fumiko Axelrod, Natasha Rozenkrantz et al. · Cancer Research · 2004 · 601 citations · Full text

Medicine, Oncology, Pharmacology +16

Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer

Johannes V. Swinnen, Tania Roskams, Steven Joniau et al. · International Journal of Cancer · 2001 · 376 citations

Medicine, Oncology, Pathology +17

Two Tandem Binding Sites for Sterol Regulatory Element Binding Proteins Are Required for Sterol Regulation of Fatty-acid Synthase Promoter

Marisa Magaña, Timothy F. Osborne · Journal of Biological Chemistry · 1996 · 330 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients

Piero Alò, Paolo Visca, Adele Marci et al. · Cancer · 1996 · 319 citations · Full text

Medicine, Cancer Biology, Oncology +17