Effect of topical application of diclofenac liposomal suspension on experimentally induced subcutaneous inflammation in horses

Abstract

A single topical application of DLS resulted in concentrations of diclofenac in transudate within 6 hours and significantly attenuated carrageenan-induced local production of PGE2. Results of this study suggest that DLS is readily absorbed transdermally and may be efficacious for reducing subcutaneous inflammation in horses.