Two independent mutational events in the loss of urate oxidase during hominoid evolution

DNA sequencing with chain-terminating inhibitors

Frederick Sanger, S. Nicklen, Alan Coulson · Proceedings of the National Academy of Sciences · 1977 · 69.3K citations · Full text

Life Sciences, Microbiology, Molecular Biology +10

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

W. David Benton, Ronald W. Davis · Science · 1977 · 4.7K citations

Life Sciences, Genetics, Molecular Biology +8

Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.

B N Ames, Richard Cathcart, Elizabeth Schwiers et al. · Proceedings of the National Academy of Sciences · 1981 · 2.9K citations · Full text

Life Sciences, Biochemistry, Physiology +17

Mitochondrial DNA sequences of primates: Tempo and mode of evolution

Wesley M. Brown, Ellen M. Prager, Alice Wang et al. · Journal of Molecular Evolution · 1982 · 1.6K citations · Full text

Life Sciences, Evolutionary Biology, Genetics +12

Nonrandom association of polymorphic restriction sites in the β-globin gene cluster

Stylianos E. Antonarakis, Corinne D. Boehm, Patricia J. Giardina et al. · Proceedings of the National Academy of Sciences · 1982 · 403 citations · Full text

Life Sciences, Genetics, Molecular Genetics +12