New and continuing developments at PROSITE

TLDR

PROSITE is a database of protein domain, family, and functional site signatures, complemented by ProRule rules that enhance pattern and profile discrimination for annotating UniProtKB/Swiss‑Prot entries. We describe recent developments that enable whole‑proteome annotation. These developments include filtering options that can be combined for powerful targeted searches. The latest version of PROSITE (release 20.85, 30 August 2012) contains 1308 patterns, 1039 profiles and 1041 ProRules.

Abstract

PROSITE (http://prosite.expasy.org/) consists of documentation entries describing protein domains, families and functional sites, as well as associated patterns and profiles to identify them. It is complemented by ProRule a collection of rules, which increases the discriminatory power of these profiles and patterns by providing additional information about functionally and/or structurally critical amino acids. PROSITE signatures, together with ProRule, are used for the annotation of domains and features of UniProtKB/Swiss-Prot entries. Here, we describe recent developments that allow users to perform whole-proteome annotation as well as a number of filtering options that can be combined to perform powerful targeted searches for biological discovery. The latest version of PROSITE (release 20.85, of 30 August 2012) contains 1308 patterns, 1039 profiles and 1041 ProRules.