Concepedia

The Antifungal Polyketide Ambruticin Targets the HOG Pathway

Leandro Vetcher, Hugo G. Menzella, Toshiaki Kudo, Takayuki Motoyama, Leonard Katz

Antimicrobial Agents and Chemotherapy · 2007 · 53 citations · 19 references

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Abstract

The polyketide ambruticin is an attractive candidate for drug development as an antifungal agent, but its mechanism of action has not yet been elucidated. Here we present evidence that ambruticin exerts its effect by targeting HOG, the osmotic stress control pathway, through Hik1, a group III histidine kinase.

References

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Osmoregulation and Fungicide Resistance: the <i>Neurospora crassa os-2</i> Gene Encodes a <i>HOG1</i> Mitogen-Activated Protein Kinase Homologue

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Characterization of mutations in the two‐component histidine kinase gene that confer fludioxonil resistance and osmotic sensitivity in the <i>os‐1</i> mutants of <i>Neurospora crassa</i>

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