(123)I-Labeled chitinase as specific radioligand for in vivo detection of fungal infections in mice.

Abstract

Our results show that (123)I-ChiB_E144Q has affinity in vitro for fungi. In vivo, the tracer accumulates in tissue infected with C. albicans and A. fumigatus but not in tissue infected with gram-positive or gram-negative bacteria, or in sterile inflammations, proving it to be a valuable SPECT diagnostic.